Basic information of NR3C1 :
| Official Symbol of Gene | NR3C1 |
| Species | Homo sapiens |
| Entrez Gene ID | 2908 |
| Official Full Name | nuclear receptor subfamily 3 group C member 1 |
| Also known as | GR; GCR; GRL; GCCR; GCRST |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000113580 MIM:138040; AllianceGenome:HGNC:7978 |
| Map Location | 5q31.3 |
| Variation Type | SNP |
| refSNP ID | rs6189/6190 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | PBMC |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranic |
| Sample Size | 300 relapsing-remitting MS patients and 300 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 31724909 |
| Year | 2019 |
| Title | Role of NR3C1 and GAS5 genes polymorphisms in Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829688 between the study groups |
| Mechanism/Pathway | the long non-coding RNA (lncRNA) growth arrest specific 5 (GAS5) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity |
