Basic information of GAS5 :
| Official Symbol of Gene | GAS5 |
| Species | Homo sapiens |
| Entrez Gene ID | 60674 |
| Official Full Name | growth arrest specific 5 |
| Also known as | SNHG2; NCRNA00030 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000234741 MIM:608280; AllianceGenome:HGNC:16355 |
| Map Location | 1q25.1 |
| Variation Type | SNP |
| refSNP ID | rs55829688 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | PBMC |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranic |
| Sample Size | 300 relapsing-remitting MS patients and 300 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 31724909 |
| Year | 2019 |
| Title | Role of NR3C1 and GAS5 genes polymorphisms in Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | We demonstrated significant differences in distribution of genotype, allele and haplotype frequencies of rs6189, rs41423247 and rs55829691 between the study groups |
| Mechanism/Pathway | the long non-coding RNA (lncRNA) growth arrest specific 5 (GAS8) interacts with GR through binding to the DNA-binding domain (DBD) region and reduces GR transcriptional activity |
