Basic information of IL4 :
| Official Symbol of Gene | IL4 |
| Species | Homo sapiens |
| Entrez Gene ID | 3565 |
| Official Full Name | interleukin 4 |
| Also known as | BSF1; IL-4; BCGF1; BSF-1; BCGF-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000113520 MIM:147780; AllianceGenome:HGNC:6014 |
| Map Location | 5q31.1 |
| Variation Type | SNP |
| refSNP ID | VNTR and +33 C/T |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | PBMC |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RR/PP/SP |
| Population | Spanish-Basque, Northern Irish and Belgian |
| Sample Size | 191 patients and 94 healthy controls of Basque origin, 267 Northern Irish MS patients and 179 healthy controls of Northern Irish descent and 126 trios of Belgian origin |
Literature information of multiple sclerosis :
| Pubmed ID | 16313303 |
| Year | 2005 |
| Title | Polymorphisms in the interleukin-4 and IL-4 receptor genes and multiple sclerosis: a study in Spanish-Basque, Northern Irish and Belgian populations |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | We did not identify IL-4–IL4-R gene–gene interaction in determining susceptibility or clinical parameters of MS. Disease or genetic heterogeneity or both may be responsible for the observed lack of reproduction in different populations. Our data reinforce recent findings for a role of IL4-R in susceptibility to MS |
| Mechanism/Pathway | genetic heterogeneity |
