Basic information of NLRP3 :
| Official Symbol of Gene | NLRP3 |
| Species | Homo sapiens |
| Entrez Gene ID | 114548 |
| Official Full Name | NLR family pyrin domain containing 3 |
| Also known as | AII; AVP; FCU; MWS; FCAS; KEFH; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; DFNA34; PYPAF1; AGTAVPRL |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000162711 MIM:606416; AllianceGenome:HGNC:16400 |
| Map Location | 1q44 |
| Variation Type | SNP |
| refSNP ID | rs35829419 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | PBMC |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Catalunya |
| Sample Size | 97RRMS |
Literature information of multiple sclerosis :
| Pubmed ID | 25586466 |
| Year | 2015 |
| Title | NLRP3 inflammasome is associated with the response to IFN-b in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | negative |
| Result | These results point to a role of the NLRP3 inflammasome and its related cytokine IL1B in the response to interferon beta in patients with relapsing-remitting multiple sclerosis. |
| Mechanism/Pathway | A trend for association was observed between rs35829419 and interferon beta response |
