Basic information of STAT4 :
| Official Symbol of Gene | STAT4 |
| Species | Homo sapiens |
| Entrez Gene ID | 6775 |
| Official Full Name | signal transducer and activator of transcription 4 |
| Also known as | SLEB11 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000138378 MIM:600558; AllianceGenome:HGNC:11365 |
| Map Location | 2q32.2-q32.3 |
| Variation Type | SNP |
| refSNP ID | rs7574865 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqMan |
| Disease | MS |
| Disease subtype | N/A |
| Population | Spanish |
| Sample Size | 575 with RA, 440 with multiple sclerosis, 700 with inflammatory bowel disease, 311 with type 1 diabetes, and 723 ethnically matched healthy control subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 18759272 |
| Year | 2008 |
| Title | Association of the STAT4 Gene With Increased Susceptibility for Some Immune-Mediated Diseases |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | The STAT4 gene is emerging as a novel common risk factor for diverse complex diseases. |
| Mechanism/Pathway | The STAT4 gene encodes a transcription factor involved in the signaling pathways of several cytokines, including interleukin-12 (IL-12), the type I interferons, and IL-23. |
