Basic information of SH2B3 :
| Official Symbol of Gene | SH2B3 |
| Species | Homo sapiens |
| Entrez Gene ID | 10019 |
| Official Full Name | SH2B adaptor protein 3 |
| Also known as | LNK; IDDM20 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000111252 MIM:605093; AllianceGenome:HGNC:29605 |
| Map Location | 12q24.12 |
| Variation Type | SNP |
| refSNP ID | rs3184504 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | N/A |
| Population | Caucasian Spanish |
| Sample Size | in a Caucasian Spanish population of 2864 multiple sclerosis (MS) patients and 2930 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20508602 |
| Year | 2010 |
| Title | The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | Our results, in addition to validating some of these loci as risk factors for MS, are consistent with shared genetic mechanisms underlying different immune-mediated diseases. |
| Mechanism/Pathway | the common and specific associated genes in the different immune-mediated diseases will be crucial in future attempts at shaping the contribution of each pathway to the different disorders and the identification of novel therapies |
