Basic information of STAT1 :
| Official Symbol of Gene | STAT1 |
| Species | Homo sapiens |
| Entrez Gene ID | 6772 |
| Official Full Name | signal transducer and activator of transcription 1 |
| Also known as | CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000115415 MIM:600555; AllianceGenome:HGNC:11362 |
| Map Location | 2q32.2 |
| Variation Type | SNP |
| refSNP ID | rs# 2066802,rs# 1547550 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | N/A |
| Detected Method | real-time TaqMan |
| Disease | MS |
| Disease subtype | RRMS,SPMS |
| Population | Caucasians and had lived in southern Italy for at least three generations |
| Sample Size | 182 patients with MS, 103 patients with chronic hepatitis C, and 118 control subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 183388947 |
| Year | 2008 |
| Title | Multiple Sclerosis and Hepatitis C Virus Infection Are Associated with Single Nucleotide Polymorphisms in Interferon Pathway Genes |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | Compared to controls, Stat1 gene polymorphisms were significantly more frequent in MS patients |
| Mechanism/Pathway | genetic variants in the IRF-1 and Stat1 genes of the IFN pathway are associated with MS and HCV infection |
