Basic information of VDR :
| Official Symbol of Gene | VDR |
| Species | Homo sapiens |
| Entrez Gene ID | 7421 |
| Official Full Name | vitamin D receptor |
| Also known as | NR1I1; PPP1R163 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000111424 MIM:601769; AllianceGenome:HGNC:12679 |
| Map Location | 12q13.11 |
| Variation Type | SNP |
| refSNP ID | ApaI(rs7975232) |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranic |
| Sample Size | 160 patients and 150 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 27423580 |
| Year | 2016 |
| Title | Predisposing role of vitamin D receptor (VDR) polymorphisms in the development ofmultiple sclerosis: A case-control study |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | negative |
| Result | AA genotype polymorphism ofApaIand BsmI (OR = 4.6 and OR= 2.52, respectively), CC genotype of TaqI (OR= 2.41) and AC genotype ofApaI (OR= 1.79) are associated with the disease status. Nevertheless, the results revealed the protective role of TT genotype of TaqI (ORs b 1), CC genotype of Apal, and GG genotype ofBsmI(ORs b 1) |
| Mechanism/Pathway | negative |
