Basic information of HLA-DQB1 :
| Official Symbol of Gene | HLA-DQB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3119 |
| Official Full Name | major histocompatibility complex, class II, DQ beta 1 |
| Also known as | IDDM1; CELIAC1; HLA-DQB |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179344 MIM:604305; AllianceGenome:HGNC:4944 |
| Map Location | 6p21.32 |
| Variation Type | Gene polymorphisms |
| refSNP ID | G511525 and D6S1666 |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Netherlands |
| Sample Size | 124 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 25671658 |
| Year | 2004 |
| Title | Inheritance mode of multiple sclerosis: the effect of HLAclass II alleles is stronger than additive |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The twolocus genotype association analysis showed that in individuals who carry only one of the risk haplotypes the risk for MS is moderately increased (odds ratio (OR) 2.82; 95% confidence interval (CI) 1.50–5.31). However, in individuals carrying two risk haplotypes the risk for MS is highly increased compared with individuals who carry no risk haplotypes (OR 37.00; 95% CI 8.31–164.74). |
| Mechanism/Pathway | follow an intermediate mode of inheritance |
