Basic information of APOE :

Official Symbol of Gene	APOE
Species	Homo sapiens
Entrez Gene ID	348
Official Full Name	apolipoprotein E
Also known as	AD2; LPG; APO-E; ApoE4; LDLCQ5
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613
Map Location	19q13.32
Variation Type	SNP
refSNP ID	rs7412 (C/T)

Sample information of multiple sclerosis:

Detected Sample	blood specimens
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	the United States
Sample Size	101 participants

Literature information of multiple sclerosis :

Pubmed ID	19244396
Year	2009
Title	ApoE alleles, depression and positive affect in multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	Hierarchical linear regression analyses suggested that after controlling for demographics, disease duration, and disability, ApoE ε2 significantly predicted increased positive affect (R2Δ = 0.05, F(1,94) = 5.44, P = 0.02) and was associated with decreased severity of depressive symptoms, although this did not reach statistical significance (R2Δ = 0.03, F(1,94) = 3.44, P = 0.06). ApoE ε4 did not significantly predict depression status.
Mechanism/Pathway	N/A