Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 11892 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | promoter polymorphism |
| refSNP ID | TNF-376A |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | microsatellite study |
| Disease | MS |
| Disease subtype | N/A |
| Population | Spainish |
| Sample Size | patients (n = 241) and control subjects (n = 288) |
Literature information of multiple sclerosis :
| Pubmed ID | 15007139 |
| Year | 2004 |
| Title | TNF-376A marks susceptibility to MS in the Spanish population A replication study |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | This study was designed as a reappraisal of the association between the TNF-376A promoter polymorphism and susceptibility to multiple sclerosis found in the Spanish population but not in other populations |
| Mechanism/Pathway | because of the higher frequency of an extended, conserved haplotype carrying the TNF-376A allele. |
