Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | gene Polymorphism |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Swedish origin,Northern Italian |
| Sample Size | 165 MS patients of Swedish origin and 54 unrelated ethnically matched control individuals, obtained from the Karolinska Institute in Stockholm, together with 141 Northern Italian MS patients and 145 unrelated ethnically matched control individuals, collected at the San Raffaele Scientific Institute in Milan, Italy |
Literature information of multiple sclerosis :
| Pubmed ID | 10505747 |
| Year | 1999 |
| Title | Analysis of an IFN-g gene (IFNG) Polymorphism in Multiple Sclerosis in Europe: Effect of Population Structure on Association with Disease |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | I2 is significantly more often transmitted to DRB1*032/*042 males, than to DRB1*032/*042 females. The odds ratio (OR) for IFNG-associated susceptibility to MS in the total Sardinian DRB1*032/*042 group was 1.88 for I2 heterozygotes but amounted to 8.235 for I3 homozygotes, suggestive of a recessive mode of inheritance |
| Mechanism/Pathway | a recessive mode of inheritance |
