Basic information of CRYAB :
| Official Symbol of Gene | CRYAB |
| Species | Homo sapiens |
| Entrez Gene ID | 1410 |
| Official Full Name | crystallin alpha B |
| Also known as | MFM2; CRYA2; CTPP2; HSPB5; CMD1II; CTRCT16; HEL-S-101 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000109846 MIM:123590; AllianceGenome:HGNC:2389 |
| Map Location | 11q23.1 |
| Variation Type | gene Polymorphism |
| refSNP ID | -C249G |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | allele-specific PCR approach |
| Disease | MS |
| Disease subtype | N/A |
| Population | Dutch |
| Sample Size | 490MS，182controls |
Literature information of multiple sclerosis :
| Pubmed ID | 14610128 |
| Year | 2003 |
| Title | αB-Crystallin genotype has impact on the multiple sclerosis phenotype |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Carriers of the rare allele CRYAB–650*C had an increased likelihood of a noninflammatory, neurodegenerative phenotype characterized by a relatively rapid, primary progressive clinical disease course. |
| Mechanism/Pathway | nfluenced susceptibility as well as disease expression in MS |
