Basic information of SERPINE1 :
| Official Symbol of Gene | SERPINE1 |
| Species | Homo sapiens |
| Entrez Gene ID | 5054 |
| Official Full Name | serpin family E member 1 |
| Also known as | PAI; PAI1; PAI-1; PLANH1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000106366 MIM:173360; AllianceGenome:HGNC:8583 |
| Map Location | 7q22.1 |
| Variation Type | insertion/deletion (I/D) genetic polymorphism |
| refSNP ID | TPA DD/PAI-1 4G4G |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | leukocytes |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | N/A |
| Population | Slovenia,Croatia |
| Sample Size | 333 MS patients,368controls |
Literature information of multiple sclerosis :
| Pubmed ID | 17986506 |
| Year | 2008 |
| Title | PAI and TPA gene polymorphisms in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | TPA DD/PAI-1 4G4G genotype combination has reached a borderline significance for reduced risk for MS |
| Mechanism/Pathway | he explanation for this interaction may be a complex interplay between these two pleiotropic proteins within the brain tissue and in plasma. |
