Basic information of HLA-DQB1 :
| Official Symbol of Gene | HLA-DQB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3119 |
| Official Full Name | major histocompatibility complex, class II, DQ beta 1 |
| Also known as | IDDM1; CELIAC1; HLA-DQB |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179344 MIM:604305; AllianceGenome:HGNC:4944 |
| Map Location | 6p21.32 |
| Variation Type | haplotypic diversity |
| refSNP ID | HLA-DQB1*0602 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | N/A |
| Disease | MS |
| Disease subtype | RRMS |
| Population | African American |
| Sample Size | nuclear family members ( n p 357), and unrelated control individuals (n p 310 |
Literature information of multiple sclerosis :
| Pubmed ID | 14669136 |
| Year | 2004 |
| Title | Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African Americans |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | A selective association with HLA-DRB1*15 was revealed, indicating a primary role for the DRB1 locus in MS independent of DQB1*0602 |
| Mechanism/Pathway | a substantial proportion of the susceptibility chromosomes from African American patients with MS displayed haplotypes consistent with an African origin. |
