Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 348 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
| Variation Type | gene polymorphism |
| refSNP ID | -491 A/T |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | leukocytes |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,SPMS |
| Population | N/A |
| Sample Size | One-hundred and twenty outpatients with clinically definite MS,107controls |
Literature information of multiple sclerosis :
| Pubmed ID | 10536914 |
| Year | 1999 |
| Title | APOE and risk of cognitive impairment in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The AA homozygous state of the -491 AIT polymorphism of the APOE regulatory region is associated with I cognitive impairment in patients with MS. |
| Mechanism/Pathway | gene polymorphism |
