Basic information of TLR3 :
| Official Symbol of Gene | TLR3 |
| Species | Homo sapiens |
| Entrez Gene ID | 7098 |
| Official Full Name | toll like receptor 3 |
| Also known as | CD283; IIAE2; IMD83 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000164342 MIM:603029; AllianceGenome:HGNC:11849 |
| Map Location | 4q35.1 |
| Variation Type | SNP |
| refSNP ID | rs377529 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | PBMC |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Cyprus |
| Sample Size | MS patients (n=27) and healthy controls (n=30) |
Literature information of multiple sclerosis :
| Pubmed ID | 31177052 |
| Year | 2019 |
| Title | Complete sequence analysis of human toll-like receptor 3 gene in natural killer cells of multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | N/A |
| Result | The alignment identified multiple substitution mutations across the five exons of the TLR3 gene (rs116729895, rs3775296, rs377529, rs3775290, rs3775291, rs376735334 and rs73873710). A significant difference was observed in the allele distribution of rs3775291 (Leu412Phe) between MS patients and HC, whereby the minor allele was detected in 38.9% ofMS patients versus 11% of HC (Fisher's exact test, p=0.023). |
| Mechanism/Pathway | TLR recognition and various cytotoxic and immunoregulatory functions |
