Basic information of Foxp3 :
| Official Symbol of Gene | Foxp3 |
| Species | Mus musculus |
| Entrez Gene ID | 20371 |
| Official Full Name | forkhead box P3 |
| Also known as | sf; JM2; scurfin |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000039521 AllianceGenome:MGI:1891436 |
| Map Location | X A1.1; X 3.41 cM |
| Variation Type | DNA methylation |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | cell |
| Sample Detail | T lymphocytes and neurons |
| Detected Method | bisulfite sequencing |
| Disease | EAE |
| Disease subtype | N/A |
| Population | Four Core Genotype model |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 29307297 |
| Year | 2018 |
| Title | Sex chromosome contributions to sex differences in multiple sclerosis susceptibility and progression |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | T lymphocyte DNA methylation studies of the X chromosome gene Foxp3 suggested that maternal versus paternal imprinting of X chromosome genes may underlie sex differences in autoimmunity. |
| Mechanism/Pathway | differential expression of the X chromosome gene Toll-like receptor 7 in neurons may contribute to sex differences in neurodegeneration. |
