Basic information of HLA-C :
| Official Symbol of Gene | HLA-C |
| Species | Homo sapiens |
| Entrez Gene ID | 4933 |
| Official Full Name | major histocompatibility complex, class I, C |
| Also known as | MHC; HLAC; HLC-C; D6S204; PSORS1; HLA-JY3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204525 MIM:142840; AllianceGenome:HGNC:4933 |
| Map Location | 6p21.33 |
| Variation Type | SNP |
| refSNP ID | HLA-DRB1*13:03:01ã€rs75589097 |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | Illumina Infinium custom genotyping array |
| Disease | MS |
| Disease subtype | N/A |
| Population | Hispanic population |
| Sample Size | 1298 MS cases and 1354 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 36548255 |
| Year | 2022 |
| Title | Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | HLA-DQB1*06:02 dominant, risk; HLA-A*2:01 additive, protective; HLA-DPB1*03:01 additive, risk; HLA-DRB1*13:03:01 additive, risk; HLA-DQB1*02:01 additive, risk; HLA-DRB1*15:01 additive, risk |
| Mechanism/Pathway | MHC is vital to proper immune system function due to its central role in the initiation of adaptive immune response |
