Basic information of IL2RA :
| Official Symbol of Gene | IL2RA |
| Species | Homo sapiens |
| Entrez Gene ID | 6008 |
| Official Full Name | interleukin 2 receptor subunit alpha |
| Also known as | p55; CD25; IL2R; IMD41; TCGFR; IDDM10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134460 MIM:147730; AllianceGenome:HGNC:6008 |
| Map Location | 10p15.1 |
| Variation Type | SNP |
| refSNP ID | rs12722598 |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | Genomic DNA Extraction and SNV Analysis |
| Disease | MS |
| Disease subtype | N/A |
| Population | Polish population |
| Sample Size | 94 MS cases and 160 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 33224992 |
| Year | 2020 |
| Title | Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The frequency of allele T was significantly higher in the control healthy group than in the group of individuals with MS |
| Mechanism/Pathway | individuals carrying the IL2RA risk alleles present a significantly increased propensity of TH (T helper) cells to develop into GM-CSF- (granulocyte-macrophage colony-stimulating factor-) producing memory TH-cells and linked this genetic risk factor with a functional feature of TH-cells in MS |
