Basic information of CTLA4 :
| Official Symbol of Gene | CTLA4 |
| Species | Homo sapiens |
| Entrez Gene ID | 2505 |
| Official Full Name | cytotoxic T-lymphocyte associated protein 4 |
| Also known as | CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000163599 MIM:123890; AllianceGenome:HGNC:2505 |
| Map Location | 2q33.2 |
| Variation Type | SNP |
| refSNP ID | rs5742906 |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | Genomic DNA Extraction and SNV Analysis |
| Disease | MS |
| Disease subtype | N/A |
| Population | Polish population |
| Sample Size | 94 MS cases and 160 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 33224992 |
| Year | 2020 |
| Title | Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Of the three polymorphisms tested in the CTLA4 gene, our study showed significant differences in allele and genotype frequencies only for rs3087243. |
| Mechanism/Pathway | The CTLA-4 gene has been associated with susceptibility to MS |
