Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 4948 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | SNP |
| refSNP ID | DRB1*1501 |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | PCR and sequence-specific oligonucleotide probes |
| Disease | MS |
| Disease subtype | Western-type MSã€Asian-type MS |
| Population | Japanese population |
| Sample Size | 53 MS cases and 113 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 8871575 |
| Year | 1996 |
| Title | Western versus Asian types of multiple sclerosis: immunogenetically and clinically distinct disorders |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | the DR2-associated DRB1*1501 allele and DRB5*0101 allele were associated with Western-type MS (41.2%), but not with either Asian-type MS (0%) or healthy control subjects (14.2%) |
| Mechanism/Pathway | suggests the importance of the DRB 1 *1501 molecule in the genera- tion of autoaggressive T cells against myelin |
