Basic information of CD58 :
| Official Symbol of Gene | CD58 |
| Species | Homo sapiens |
| Entrez Gene ID | 1688 |
| Official Full Name | CD58 molecule |
| Also known as | ag3; LFA3; LFA-3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000116815 MIM:153420; AllianceGenome:HGNC:1688 |
| Map Location | 1p13.1 |
| Variation Type | SNP |
| refSNP ID | rs1335532 |
Sample information of multiple sclerosis:
| Detected Sample | Daudi lymphoblastic cell lineã€Raji cell lineã€U937 cell line |
| Sample Detail | N/A |
| Detected Method | Luciferase reporter constructs |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 3006149 |
| Year | 2018 |
| Title | Protective C allele of the single-nucleotide polymorphism rs1335532 is associated with strong binding of Ascl2 transcription factor and elevated CD58 expression in B-cells |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | CD58 enhancer 2 containing SNP rs1335532 demonstrated 2-fold up-regulating effect on CD58 promoter activity |
| Mechanism/Pathway | The minor rs1335532 allelic variant is associated with elevated CD58 promoter activity in lymphoblastic cell lines upon Wnt/β-catenin signaling pathway activation |
