Basic information of IL10 :
| Official Symbol of Gene | IL10 |
| Species | Homo sapiens |
| Entrez Gene ID | 5962 |
| Official Full Name | interleukin 10 |
| Also known as | CSIF; TGIF; GVHDS; IL-10; IL10A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000136634 MIM:124092; AllianceGenome:HGNC:5962 |
| Map Location | 1q32.1 |
| Variation Type | Gene polymorphisms |
| refSNP ID | L-10 - 1082 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Finnish population |
| Sample Size | 116 MS cases and 400 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 14616291 |
| Year | 2003 |
| Title | Promoter polymorphism of IL-10 and severity of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The AG genotype of IL-10 proved to be protective against severe MS in all patients (OR=0.32, P=0.010), the effect being increased over the years |
| Mechanism/Pathway | higher doses of IL-10 appear toinduce the expression of Th1 cytokines |
