Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 613 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
| Variation Type | Gene polymorphisms |
| refSNP ID | E4 - ε2 |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | Datebase |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 221 MS cases |
Literature information of multiple sclerosis :
| Pubmed ID | 15007140 |
| Year | 2004 |
| Title | Association of APOE polymorphisms with disease severity in MS is limited to women |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Women carriers of the E4*epsilon2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers |
| Mechanism/Pathway | The interaction between gender and APOE alleles could be one factor explaining the relatively favorable outcome for women with MS |
