Basic information of CIITA :
| Official Symbol of Gene | CIITA |
| Species | Homo sapiens |
| Entrez Gene ID | 7067 |
| Official Full Name | class II major histocompatibility complex transactivator |
| Also known as | C2TA; NLRA; MHC2TA; CIITAIV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179583 MIM:600005; AllianceGenome:HGNC:7067 |
| Map Location | 16p13.13 |
| Variation Type | SNP |
| refSNP ID | rs4774 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqMan ABI 7900 |
| Disease | MS |
| Disease subtype | N/A |
| Population | Swedish population |
| Sample Size | 2003 MS cases and 1672 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 24430172 |
| Year | 2014 |
| Title | Variability in the CIITA gene interacts with HLA in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result |
A significant association ofrs4774 (P |
| Mechanism/Pathway | The DRB1 locus in the HLA class II region is the major established genetic determinant of disease risk in MS that makes interaction between these loci plausible for any possible association with the CIITA gene |
