Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 4948 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | SNP |
| refSNP ID | DRB1*15:01 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqMan ABI 7900 |
| Disease | MS |
| Disease subtype | N/A |
| Population | Swedish population |
| Sample Size | 2003 MS cases and 1672 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 24430172 |
| Year | 2014 |
| Title | Variability in the CIITA gene interacts with HLA in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We find that the previously investigated single-nucleotide polymorphism rs4774 is associated with MS risk in cases carrying the HLA-DRB1*15 allele |
| Mechanism/Pathway | The DRB1 locus in the HLA class II region is the major established genetic determinant of disease risk in MS that makes interaction between these loci plausible for any possible association with the CIITA gene |
