Basic information of AGER :
| Official Symbol of Gene | AGER |
| Species | Homo sapiens |
| Entrez Gene ID | 320 |
| Official Full Name | advanced glycosylation end-product specific receptor |
| Also known as | RAGE; sRAGE; SCARJ1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204305 MIM:600214; AllianceGenome:HGNC:320 |
| Map Location | 6p21.32 |
| Variation Type | Gene polymorphisms |
| refSNP ID | p.82G>S |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Chinese population |
| Sample Size | 144 MS cases and 156 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 21511691 |
| Year | 2011 |
| Title | A functional p.82G>S polymorphism in the RAGE gene is associated with multiple sclerosis in the Chinese population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The present study provides preliminary evidence that the gain-of-function p.82G>S polymorphism in the RAGE gene is associated with an increased risk of MS in the Chinese population |
| Mechanism/Pathway | The receptor for advanced glycation end products (RAGE) and its proinflammatory ligand, S100-calgranulins, are critically implicated in the pathological progression of multiple sclerosis |
