Basic information of KDR :
| Official Symbol of Gene | KDR |
| Species | Homo sapiens |
| Entrez Gene ID | 6307 |
| Official Full Name | kinase insert domain receptor |
| Also known as | FLK1; CD309; VEGFR; VEGFR2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000128052 MIM:191306; AllianceGenome:HGNC:6307 |
| Map Location | 4q12 |
| Variation Type | SNP |
| refSNP ID | rs2071559 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-RFLP |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 400 MS cases and 400 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 28401369 |
| Year | 2017 |
| Title | The Importance of VEGF-KDR Signaling Pathway Genes should Not Be Ignored When the Risk of Developing Multiple Sclerosis is Taken into Consideration |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | the KDR -604T > C (rs2071559) polymorphism showed no significant difference in either allelic or genotype frequency between the two groups |
| Mechanism/Pathway | VEGF and KDR pathway trigger the process of angiogenesis as well as inflammation, which contributes to the development and progression of demyelinating lesions in multiple sclerosis |
