Basic information of MOG :
| Official Symbol of Gene | MOG |
| Species | Homo sapiens |
| Entrez Gene ID | 7197 |
| Official Full Name | myelin oligodendrocyte glycoprotein |
| Also known as | BTN6; BTNL11; MOGIG2; NRCLP7 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204655 MIM:159465; AllianceGenome:HGNC:7197 |
| Map Location | 6p22.1 |
| Variation Type | SNP |
| refSNP ID | rs3130253 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 179 MS cases |
Literature information of multiple sclerosis :
| Pubmed ID | 31228212 |
| Year | 2020 |
| Title | Post-mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Three SNPs linked to MS pathology-associated genes showed a significant association with either proportion of active lesions (rs3130253/MOG), incidence of cortical gray matter lesions (rs1064395/NCAN) or the proportion of remyelinated lesions (rs5742909/CTLA4) |
| Mechanism/Pathway | This is in part because of the difficulty in the functional translation of genotype into disease-relevant mechanisms |
