Basic information of HLA-C :
| Official Symbol of Gene | HLA-C |
| Species | Homo sapiens |
| Entrez Gene ID | 4933 |
| Official Full Name | major histocompatibility complex, class I, C |
| Also known as | MHC; HLAC; HLC-C; D6S204; PSORS1; HLA-JY3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204525 MIM:142840; AllianceGenome:HGNC:4933 |
| Map Location | 6p21.33 |
| Variation Type | SNP |
| refSNP ID | rs2647040 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqManã€PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | African Americans population |
| Sample Size | 499 MS cases and 750 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20466734 |
| Year | 2010 |
| Title | Refining the association of MHC with multiple sclerosis in African Americans |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Two MHC class II SNPs, rs2647040 and rs3135021, were significant in the replication cohort and partially tagged DRB1*15 alleles. |
| Mechanism/Pathway | Although the association of these two SNPs may be derived from their partial tagging of HLA-DRB1*15 alleles, it is still of interest to discuss other loci close to the SNPs. it is still possible that other alleles of DQB1 are associated independently of DRB1 with MS susceptibility in African Americans |
