Basic information of HLA-C :
| Official Symbol of Gene | HLA-C |
| Species | Homo sapiens |
| Entrez Gene ID | 4933 |
| Official Full Name | major histocompatibility complex, class I, C |
| Also known as | MHC; HLAC; HLC-C; D6S204; PSORS1; HLA-JY3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204525 MIM:142840; AllianceGenome:HGNC:4933 |
| Map Location | 6p21.33 |
| Variation Type | SNP |
| refSNP ID | rs3135021 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqManã€PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | African Americans population |
| Sample Size | 499 MS cases and 750 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20466734 |
| Year | 2010 |
| Title | Refining the association of MHC with multiple sclerosis in African Americans |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Two MHC class II SNPs, rs2647040 and rs3135021, were significant in the replication cohort and partially tagged DRB1*15 alleles. |
| Mechanism/Pathway | It is therefore possible that the association of rs3135021 with MS in African Americans may be through HLA-DPB1 rather than HLA-DRB1 alleles. |
