Basic information of MIR137 :
| Official Symbol of Gene | MIR137 |
| Species | Homo sapiens |
| Entrez Gene ID | 31523 |
| Official Full Name | microRNA 137 |
| Also known as | MIRN137; miR-137 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000284202 MIM:614304; miRBase:MI0000454; AllianceGenome:HGNC:31523 |
| Map Location | 1p21.3 |
| Variation Type | SNP |
| refSNP ID | rs1625579 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqManã€qPCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | n = 108 (case group)/n = 104 (control group) |
Literature information of multiple sclerosis :
| Pubmed ID | 32348112 |
| Year | 2020 |
| Title | LncRNA GAS5 and miR-137 Polymorphisms and Expression are Associated with Multiple Sclerosis Risk: Mechanistic Insights and Potential Clinical Impact |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The rs2067079TT minor homozygote genotype was associated with an increased MS risk, while the rs1625579G minor allele was protectiveï¼›rs1625579 showed an age-specific effect, while the rs2067079 affected the MS risk in gender- and age-specific manners |
| Mechanism/Pathway | The long noncoding RNA GAS5 acts as a competing endogenous RNA for microRNA-137 and is involved in demyelination |
