Basic information of AGER :

Official Symbol of Gene	AGER
Species	Homo sapiens
Entrez Gene ID	320
Official Full Name	advanced glycosylation end-product specific receptor
Also known as	RAGE; sRAGE; SCARJ1
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000204305 MIM:600214; AllianceGenome:HGNC:320
Map Location	6p21.32
Variation Type	SNP
refSNP ID	rs2070600

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	TaqMan
Disease	MS
Disease subtype	N/A
Population	African Americans
Sample Size	769 MS cases and 742 controls and 124 parents

Literature information of multiple sclerosis :

Pubmed ID	18832704
Year	2008
Title	Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	Both AGER SNPs showed evidence for association when conditioned on the DRB1 genotype using WHAP (p < 0.01 for rs1035798 in African Americans and p < 0.0001 for rs2070600 in whites, data not shown), which were similar to results shown for the conditional haplotype analysis (Tables IV and andVI).VI). This is compatible with independent contributions from both AGER and DRB1 to MS susceptibility
Mechanism/Pathway	conditional haplotype analysis revealed a susceptibility signal at the class III AGER locus independent of DRB1