Basic information of HIF1A :
| Official Symbol of Gene | HIF1A |
| Species | Homo sapiens |
| Entrez Gene ID | 4910 |
| Official Full Name | hypoxia inducible factor 1 subunit alpha |
| Also known as | HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; HIF-1-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000100644 MIM:603348; AllianceGenome:HGNC:4910 |
| Map Location | 14q23.2 |
| Variation Type | SNP |
| refSNP ID | rs11549465 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 150 MS cases and 150 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31652374 |
| Year | 2019 |
| Title | The evaluation of VEGF and HIF-1α gene polymorphisms and multiple sclerosis susceptibility |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | our results do not show a significant association between MS and HIF-1α polymorphisms |
| Mechanism/Pathway | Some lines of evidence, suchas an increased protein level of HIF-1α, increased expression ofhypoxia-inducible genes in lesions and a reduction in blood flow inthe adjacent normal-appearing white matter of the lesion, supportthe role of hypoxia in early MS |
