Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 4948 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | SNP |
| refSNP ID | DRB1*1501 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | Western-type MSã€Asian-type MS |
| Population | Japanese population |
| Sample Size | 80 MS cases （42 Western-type MS cases and 38 Asian-type MS cases）and 85 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 9916885 |
| Year | 1998 |
| Title | HLA-DRB1 and tumor necrosis factor gene polymorphisms in Japanese patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The frequency of HLA-DRB1 * 1501 allele in the Western-type MS group increased significantly compared with the control group, while Asian-type MS and control groups showed similar distribution in the frequencies of HLA-DRB1 alleles |
| Mechanism/Pathway | The results suggest that MS in Asians may present two different clinical and immunogenetic manifestations |
