Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 11892 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | Gene polymorphisms |
| refSNP ID | exon 10 nt 1668*T-->G |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR-SSP |
| Disease | MS |
| Disease subtype | N/A |
| Population | Austrian population |
| Sample Size | 321 MS cases and 174 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 14651520 |
| Year | 2004 |
| Title | Genetic variants in the tumor necrosis factor receptor II gene in patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We found a significant association between exon 10 nt 1668*T-->G polymorphism and susceptibility to MS |
| Mechanism/Pathway | Thus, TNFR II polymorphism appears to contuibute to the suscepbility to MS but not to its phenotype or clinical severity |
