Basic information of APOE :
| Official Symbol of Gene | APOE |
| Species | Homo sapiens |
| Entrez Gene ID | 613 |
| Official Full Name | apolipoprotein E |
| Also known as | AD2; LPG; APO-E; ApoE4; LDLCQ5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000130203 MIM:107741; AllianceGenome:HGNC:613 |
| Map Location | 19q13.32 |
| Variation Type | Gene polymorphisms |
| refSNP ID | ε4 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Austrian population |
| Sample Size | 72 MS cases |
Literature information of multiple sclerosis :
| Pubmed ID | 12533090 |
| Year | 2003 |
| Title | Lower levels of N-acetylaspartate in multiple sclerosis patients with the apolipoprotein E epsilon4 allele |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | During follow-up, the drop in the N-acetylaspartate-creatine ratio of epsilon4 carriers was also significantly larger (-0.31 vs -0.10; P =.01) |
| Mechanism/Pathway | The APOE epsilon4 allele has a negative effect on the course of MS, and increasing axonal damage may be an important mechanism |
