Basic information of CTLA4 :
| Official Symbol of Gene | CTLA4 |
| Species | Homo sapiens |
| Entrez Gene ID | 2505 |
| Official Full Name | cytotoxic T-lymphocyte associated protein 4 |
| Also known as | CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000163599 MIM:123890; AllianceGenome:HGNC:2505 |
| Map Location | 2q33.2 |
| Variation Type | SNP |
| refSNP ID | rs3087243 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCRã€SNaPshot |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 152 MS cases and 154 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 15180809 |
| Year | 2004 |
| Title | Progression of multiple sclerosis is associated with exon 1 CTLA-4 gene polymorphism |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Those MS patients with AA and AG genotypes had 4.36 times greater risk of progressing from the relapsing-remitting to the secondary progressive form of the disease than those with the GG genotype |
| Mechanism/Pathway | CTLA-4 antigen molecule plays a key role in the downregulation of T-cell responses |
