Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 11892 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
| Variation Type | Gene polymorphisms |
| refSNP ID | TNF - 238 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Dutch population |
| Sample Size | 57 MS patients in a nursing home 98 MS patients in an outpatient's clinic and 180 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 9042107 |
| Year | 1997 |
| Title | TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | These results suggest that the -238 GG genotype is differently distributed in hospitalized MS patients in a nursing home;The -238 G to A polymorphism is differently distributed in hospitalized MS patients in a nursing home compared to healthy controls |
| Mechanism/Pathway | TNF-α promoter polymorphisms and susceptibility to MS |
