Basic information of CD40 :
| Official Symbol of Gene | CD40 |
| Species | Homo sapiens |
| Entrez Gene ID | 11919 |
| Official Full Name | CD40 molecule |
| Also known as | p50; Bp50; CDW40; TNFRSF5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000101017 MIM:109535; AllianceGenome:HGNC:11919 |
| Map Location | 20q13.12 |
| Variation Type | SNP |
| refSNP ID | rs1883832 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqManã€qPCR |
| Disease | MS |
| Disease subtype | RRMSã€PPMSã€SPMS and CIS |
| Population | Russian population |
| Sample Size | 1684 MS cases and 879 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 23613777 |
| Year | 2013 |
| Title | Association of SNPs of CD40 gene with multiple sclerosis in Russians |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In our study, both SNPs rs6074022 and rs1883832 were significantly associated with MS |
| Mechanism/Pathway | We may speculate that the functional variant(s) is likely to be located in the upstream region of the gene CD40 and is in higher LD with rs6074022 than with rs1883832 |
