Basic information of CASP9 :
| Official Symbol of Gene | CASP9 |
| Species | Homo sapiens |
| Entrez Gene ID | 1511 |
| Official Full Name | caspase 9 |
| Also known as | MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000132906 MIM:602234; AllianceGenome:HGNC:1511 |
| Map Location | 1p36.21 |
| Variation Type | Gene polymorphisms |
| refSNP ID | CASP9 G/G |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Italian population |
| Sample Size | 295 MS cases and 295 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 19359048 |
| Year | 2009 |
| Title | CASP-9: A susceptibility locus for multiple sclerosis in Italy |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Our results suggest that the presence of the G/G genotype represents a higher risk factor in our MS population and a differential production of CASP-9 might be a contributory factor in determining the severity of MS |
| Mechanism/Pathway | Caspase-9 is a primary effector CASP that executes programmed cell death, which plays an important role in the development of multiple sclerosis |
