Basic information of RORA :
| Official Symbol of Gene | RORA |
| Species | Homo sapiens |
| Entrez Gene ID | 10258 |
| Official Full Name | RAR related orphan receptor A |
| Also known as | ROR1; ROR2; ROR3; RZRA; NR1F1; RORa1; IDDECA; RORalpha; RZR-ALPHA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000069667 MIM:600825; AllianceGenome:HGNC:10258 |
| Map Location | 15q22.2 |
| Variation Type | SNP |
| refSNP ID | rs11639084 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 170 MS cases （responder (n = 105) and nonresponder (n = 65) groups） and 200 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31649263 |
| Year | 2019 |
| Title | The efficacy of interferon-beta therapy in multiple sclerosis patients: investigation of the RORA gene as a predictive biomarker |
Results of multiple sclerosis :
| Risk Type | Treatment risk |
| Main Result | Positive |
| Result | However, the allele and genotype frequencies of rs11639084 were not different between controls, nonresponder, and responder patients |
| Mechanism/Pathway | The obtained results of the present study suggested the rs4774388 as a possible effective factor in determination of response to IFN-β |
