Basic information of IL4R :
| Official Symbol of Gene | IL4R |
| Species | Homo sapiens |
| Entrez Gene ID | 6015 |
| Official Full Name | interleukin 4 receptor |
| Also known as | CD124; IL4RA; IL-4RA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000077238 MIM:147781; AllianceGenome:HGNC:6015 |
| Map Location | 16p12.1 |
| Variation Type | Gene polymorphisms |
| refSNP ID | R551 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | PPMS |
| Population | German population |
| Sample Size | 341 MS cases and 305 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 11164908 |
| Year | 2001 |
| Title | Analysis of interleukin-4 receptor alpha chain variants in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | However, further analysis of all 341 MS patients did not confirm the finding that this IL4R variant represents a general genetic risk factor for MS .After correction for multiple comparisons only the genotype differences between PPMS patients and healthy controls remained statistically significant |
| Mechanism/Pathway | nalysis of the first 100 MS patients for six IL4R variants showed an increased frequency of the R551 variant in MS patients versus healthy controls and carriage of the same IL4R variant was weakly associated with myelin oligodendrocyte glycoprotein (MOG) autoantibody production |
