Basic information of TNF :

Official Symbol of Gene	TNF
Species	Homo sapiens
Entrez Gene ID	11892
Official Full Name	tumor necrosis factor
Also known as	DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892
Map Location	6p21.33
Variation Type	Gene polymorphisms
refSNP ID	TNF-alpha -308 G/A

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	SSP-PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	366 MS cases and 414 controls

Literature information of multiple sclerosis :

Pubmed ID	21396892
Year	2011
Title	Interaction of HLA-DRB1*1501 allele and TNF-alpha -308 G/A single nucleotide polymorphism in the susceptibility to multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Positive
Result	TNF-α -308 G allele and G/G genotype had higher frequency among MS patients than control subjects
Mechanism/Pathway	It is believed that genes encoding HLA molecule and cytokines are involved in the pathogenesis of MS