Basic information of NR3C1 :
| Official Symbol of Gene | NR3C1 |
| Species | Homo sapiens |
| Entrez Gene ID | 7978 |
| Official Full Name | nuclear receptor subfamily 3 group C member 1 |
| Also known as | GR; GCR; GRL; GCCR; GCRST |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000113580 MIM:138040; AllianceGenome:HGNC:7978 |
| Map Location | 5q31.3 |
| Variation Type | Gene polymorphisms |
| refSNP ID | Haplotype 6 (TthIIII, ER2223EK, and 9beta-G |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqMan PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Dutch Caucasian patients |
| Sample Size | 646 MS cases and 317 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 19318444 |
| Year | 2009 |
| Title | A glucocorticoid receptor gene haplotype (TthIII1/ER22/23EK/9beta) is associated with a more aggressive disease course in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Haplotype 6 (TthIIII, ER2223EK, and 9beta-G) was associated with a more rapid disease progression |
| Mechanism/Pathway | glucocorticoids might not be sufficiently able to restrain the immune system |
