Basic information of TNFRSF1A :
| Official Symbol of Gene | TNFRSF1A |
| Species | Homo sapiens |
| Entrez Gene ID | 11916 |
| Official Full Name | TNF receptor superfamily member 1A |
| Also known as | FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000067182 MIM:191190; AllianceGenome:HGNC:11916 |
| Map Location | 12p13.31 |
| Variation Type | SNP |
| refSNP ID | rs4149577 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RT-PCRã€TaqMan PCR |
| Disease | MS |
| Disease subtype | RRMSã€SPMSã€PPMS |
| Population | Caucasian population |
| Sample Size | 497 MS cases and 878 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 25684197 |
| Year | 2015 |
| Title | Association of TNFAIP3 and TNFRSF1A variation with multiple sclerosis in a German case-control cohort |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | the intronic SNP rs1800693 in TNFRSF1A showed moderate association with MS |
| Mechanism/Pathway | evidence is accumulating that polymorphisms in both TNFAIP3 and TNFRSF1A genes play a role in MS pathogenesis |
