Basic information of PHGDH :
| Official Symbol of Gene | PHGDH |
| Species | Homo sapiens |
| Entrez Gene ID | 8923 |
| Official Full Name | phosphoglycerate dehydrogenase |
| Also known as | NLS; PDG; PGD; NLS1; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; PHGDHD; HEL-S-113 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000092621 MIM:606879; AllianceGenome:HGNC:8923 |
| Map Location | 1p12 |
| Variation Type | SNP |
| refSNP ID | rs666930 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 195 MS cases and 60 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31004050 |
| Year | 2019 |
| Title | MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | After FDR correction, we found a significant influence of the TT genotype of the rs666930 SNP (located in the phosphoglycerate dehydrogenase gene —PHGDH) on baseline MKO3 and MAP2K1 phosphorylation in MS patients |
| Mechanism/Pathway | The changes in the activation of these kinases suggest that these pathways may represent therapeutic targets for modulation by kinase inhibitors. |
