Basic information of IRF8 :
| Official Symbol of Gene | IRF8 |
| Species | Homo sapiens |
| Entrez Gene ID | 5358 |
| Official Full Name | interferon regulatory factor 8 |
| Also known as | ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000140968 MIM:601565; AllianceGenome:HGNC:5358 |
| Map Location | 16q24.1 |
| Variation Type | SNP |
| refSNP ID | rs35929052 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 195 MS cases and 60 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31004050 |
| Year | 2019 |
| Title | MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | the CT genotype of the rs35929052 SNP [located on IFN regulatory factor 8 (IRF8) gene, a key target of vitamin D receptor; refs. 11 and 12] had a significant influence on MAP2K1 phosphorylation after stimulation with vitamin D3 |
| Mechanism/Pathway | The changes in the activation of these kinases suggest that these pathways may represent therapeutic targets for modulation by kinase inhibitors. |
