Basic information of CTLA4 :
| Official Symbol of Gene | CTLA4 |
| Species | Homo sapiens |
| Entrez Gene ID | 2505 |
| Official Full Name | cytotoxic T-lymphocyte associated protein 4 |
| Also known as | CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000163599 MIM:123890; AllianceGenome:HGNC:2505 |
| Map Location | 2q33.2 |
| Variation Type | Gene polymorphisms |
| refSNP ID | intergenic CT60 SNPs |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | The Northern Ireland population |
| Sample Size | 246 RRMS patients, 84 PPMS patients, and 158 HCs |
Literature information of multiple sclerosis :
| Pubmed ID | 17524498 |
| Year | 2007 |
| Title | CTLA4 gene polymorphisms and multiple sclerosis in Northern Ireland |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | We did not find any association with the promoter (-318 C/T) or intergenic CT60 SNPs in either of the disease cohorts |
| Mechanism/Pathway | The CTLA-4 gene has receibed widespread attention as plausible candidate susceptibility gene for MS |
